Hydrochloric Acid → P 276-00

HRID 553276Notes

Reaction equation

HRID 553276 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[C:15]([C:16](=[O:18])[CH:17]=1)=[C:14]([O:19]C)[CH:13]=[C:12]([O:21]C)[C:11]=2[C@@H:23]1[CH2:27][CH2:26][N:25]([CH3:28])[C@H:24]1[CH2:29][OH:30].Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[C:15]([C:16](=[O:18])[CH:17]=1)=[C:14]([OH:19])[CH:13]=[C:12]([OH:21])[C:11]=2[C@@H:23]1[CH2:27][CH2:26][N:25]([CH3:28])[C@H:24]1[CH2:29][OH:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59318486(+)-trans-2-(2-Chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one

Product 1

HCID 23643975P 276-00

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(+)-trans-2-(2-Chlorophenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one (0.2 g, 0.48 mmol) was suspended in methanol (2 mL) and ethereal HCl (5 mL) was added. The suspension was stirred to get a clear solution. The solution was concentrated under reduced pressure to obtain the title compound.

Workup

  1. customto get a clear solution
  2. concentrationThe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-9c160ae55da34d50b200614afaff8436
Source dataset
uspto-grants-2011_05
Patent number
US07951961B2

Reaction notes

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