Acetyl chloride → Methyl 2-(3-bromophenyl)acetate

HRID 553293Notes

Reaction equation

HRID 553293 reaction equation
[C:1](Cl)(=O)C.[Br:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([OH:15])=[O:14])[CH:9]=[CH:10][CH:11]=1>CO>[CH3:1][O:14][C:13](=[O:15])[CH2:12][C:8]1[CH:9]=[CH:10][CH:11]=[C:6]([Br:5])[CH:7]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 74653(3-Bromophenyl)acetic acid

Product 1

HCID 11746402Methyl 2-(3-bromophenyl)acetate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Acetyl chloride (5 mL) was added to a solution of (3-bromo-phenyl)-acetic acid (10 g) in methanol (250 mL). Evaporation after 24 hours afforded the subtitle product, as an oil (10.9 g).

Workup

  1. customEvaporation after 24 hours

Sources & evidence

ORD record
ord-e87e49a88e694d5ba7254c3cfa76baa7
Source dataset
uspto-grants-2011_05
Patent number
US07951954B2

Reaction notes

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