Triethylamine → HCID 44596878, compound

HRID 553559Notes

Reaction equation

HRID 553559 reaction equation
C(N(CC)CC)C.Br[C:9]1[CH:10]=[C:11]2[C:16](=[C:17](Br)[C:18]=1[O:19][CH3:20])[CH2:15][N:14]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C@@:13]([CH3:32])([C:29]([OH:31])=[O:30])[CH2:12]2>CO.[Pd]>[C:25]([O:24][C:22]([N:14]1[C@@:13]([CH3:32])([C:29]([OH:31])=[O:30])[CH2:12][C:11]2[C:16](=[CH:17][C:18]([O:19][CH3:20])=[CH:9][CH:10]=2)[CH2:15]1)=[O:23])([CH3:28])([CH3:27])[CH3:26]

Participants

5

Reactant 2

HCID 8471TriethylamineHCID 44596874HCID 44596874, compound

Product 1

HCID 44596878HCID 44596878, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Triethylamine (303 mg, 3 mmol) and 10% Pd—C (20 mg) were added to Compound 2.7 (500 mg, 1.05 mmol) in MeOH (5 mL) and the mixture was hydrogenated on a Parr shaker at 40 PSI for 90 min. The mixture was filtered through Celite and concentrated. The product was used in the next step.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-b7a03a23ac1d482f9a471ec582f4aadc
Source dataset
uspto-grants-2011_11
Patent number
US08048895B2

Reaction notes

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