反应详情

温度

115 °C

To a mixture of 2-(4-bromo-benzoyl)-3-oxo-butyric acid methyl ester (11 g, 39 mmol) in acetic acid (50 mL) was added hydroxylamine hydrochloride (2.66 g, 39 mmol), and the reaction was stirred at 115° C. for 1 hours. After cooling, saturated aqueous NaHCO3 was added to the mixture to adjust to pH 8. The solution was extracted with EtOAc, and the combined organic layers were washed with brine, dried, filtered, and concentrated to give the title compound.

1. temperatureAfter cooling
2. extractionThe solution was extracted with EtOAc
3. washthe combined organic layers were washed with brine
4. customdried
5. filtrationfiltered
6. concentrationconcentrated