Ethyl Acetoacetate → HCID 178429290, compound

HRID 553815Notes

Reaction equation

HRID 553815 reaction equation
Cl.[C:2]([NH2:10])(=[NH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:11](OCC)(=[O:16])[CH2:12][C:13]([CH3:15])=O.C[O-].[Na+]>CCO>[CH3:15][C:13]1[N:10]=[C:2]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[N:9]=[C:11]([OH:16])[CH:12]=1

Participants

5

Reactant 3

HCID 8868Ethyl AcetoacetateHCID 80289Benzamidine, hydrochlorideHCID 10942334Sodium Methoxide

Product 1

HCID 178429290HCID 178429290, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Benzamidine hydrochloride (1.56 g), ethyl acetoacetate (1.26 ml) and sodium methoxide (30% in MeOH, 3.7 ml) were dissolved in EtOH (10 ml) and the resulting mixture was refluxed overnight. It was cooled down and the white suspension was filtered off. The solid was washed with water and high-vacuum dried. 1.83 g of a white solid were obtained.

Workup

  1. temperaturethe resulting mixture was refluxed overnight
  2. temperatureIt was cooled down
  3. filtrationthe white suspension was filtered off
  4. washThe solid was washed with water and high-vacuum
  5. customdried

Sources & evidence

ORD record
ord-4fb09cf50e17415c9542972331903827
Source dataset
uspto-grants-2011_11
Patent number
US08048881B2

Reaction notes

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