反应详情

2-(4-Acetylamino-2-isopropyl-5-methylphenoxy)ethylamine (1.0 g) and triethylamine (0.50 g) were dissolved in N,N-dimethylformamide (20 ml), and 3-hydroxy-6-methoxy-2,4,5-trimethylbenzyl chloride (0.86 g) dissolved in N,N-dimethylformamide (10 ml) was added dropwise while stirring the mixture at room temperature. The mixture was stirred for 5 hours. After the completion of the reaction, the solvent was distilled off, and water and ethyl acetate were added. The mixture was stirred and an insoluble matter was collected by filtration. The obtained solid was recrystallized from ethyl acetate to give 100 mg of the title compound.

1. additionwas added dropwise
2. stirringThe mixture was stirred for 5 hours
3. customAfter the completion of the reaction
4. distillationthe solvent was distilled off
5. additionwater and ethyl acetate were added
6. stirringThe mixture was stirred
7. filtrationan insoluble matter was collected by filtration
8. customThe obtained solid was recrystallized from ethyl acetate