Iodine → HCID 67461640, compound

HRID 553984Notes

Reaction equation

HRID 553984 reaction equation
I[Si](C)(C)C.[F:6][C:7]1[CH:8]=[C:9]([C@@H:15]2[CH2:24][CH2:23][CH2:22][C@H:21]3[N:16]2[C:17](=[O:25])[CH2:18][CH2:19][CH2:20]3)[CH:10]=[C:11]([F:14])[C:12]=1[F:13].CN(C)CCN(C)C.[I:34]I.S([O-])([O-])(=O)=S.[Na+].[Na+]>C(Cl)Cl.C(OCC)(=O)C>[F:14][C:11]1[CH:10]=[C:9]([C@@H:15]2[CH2:24][CH2:23][CH2:22][C@H:21]3[N:16]2[C:17](=[O:25])[CH:18]([I:34])[CH2:19][CH2:20]3)[CH:8]=[C:7]([F:6])[C:12]=1[F:13]

Participants

8

Reactant 5

HCID 807IodineHCID 8037N,N,N',N'-TetramethylethylenediamineHCID 24477Sodium ThiosulfateHCID 85247Trimethylsilyl iodideHCID 67460827HCID 67460827, compound

Product 1

HCID 67461640HCID 67461640, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

Iodotrimethylsilane (1.41 mL) was added to a solution of (6S,9aR)-6-(3,4,5-trifluorophenyl)octahydroquinolizin-4-one (1.79 g) and N,N,N′,N′tetramethylethylenediamine (3.34 mL) in methylene chloride (50 mL) in a nitrogen atmosphere at 0° C., and the reaction solution was stirred at 0° C. for 30 minutes. Iodine (2.41 g) was added to the reaction solution at 0° C., and the reaction solution was stirred at 0° C. for one hour. Ethyl acetate and a saturated sodium thiosulfate solution were added to the reaction solution, and the organic layer was separated. The resulting organic layer was washed with brine, dried over magnesium sulfate, and then concentrated under reduced pressure to obtain (6S,9aR)-6-(3,4,5-trifluorophenyl)-3-iodooctahydroquinolizin-4-one. A mixture of (6S,9aR)-6-(3,4,5-trifluorophenyl)-3-iodooctahydroquinolizin-4-one with triethyl phosphite (20 mL) was stirred at 120° C. for three hours. The reaction solution was left to cool to room temperature, and then the reaction solution was concentrated under reduced pressure. Lithium hydroxide monohydrate (792 mg) was added to a mixed solution of the residue and 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde (1.64 g) in tetrahydrofuran (45 mL) and ethanol (15 mL) at room temperature, and the reaction solution was stirred at room temperature for four hours. Ethyl acetate was added to the reaction solution, which was then sequentially washed with saturated sodium bicarbonate water and brine. The resulting organic layer was dried over magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (carrier: Chromatorex NH; elution solvent: heptane-ethyl acetate system) and then by silica gel column chromatography (elution solvent: heptane-ethyl acetate system->ethyl acetate-methanol system) to obtain 2.46 g of the title compound. The property values of the compound are as follows.

Workup

  1. stirringthe reaction solution was stirred at 0° C. for one hour
  2. customthe organic layer was separated
  3. washThe resulting organic layer was washed with brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-348f01d70df843099238f72b3a9f8225
Source dataset
uspto-grants-2011_11
Patent number
US08048878B2

Reaction notes

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