Benzaldehyde → (S)-1-Benzyl-5-carboxy-2-pyrrolidinone

HRID 554124Notes

Reaction equation

HRID 554124 reaction equation
Cl[C:2]1[C:7](C(F)(F)F)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:12][NH:13][C:14](=[O:26])[C@@H:15]1[CH2:19][CH2:18][C:17](=[O:20])N1CC(C)(C)C.C(=[O:34])C1C=CC=CC=1>>[O:26]=[C:14]1[N:13]([CH2:12][C:3]2[CH:2]=[CH:7][CH:6]=[CH:5][CH:4]=2)[C@H:18]([C:17]([OH:20])=[O:34])[CH2:19][CH2:15]1

Participants

3

Reactant 2

HCID 240BenzaldehydeHCID 67460075N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-(2,2-dimethylpropyl)-5-oxoprolinamide

Product 1

HCID 10900113(S)-1-Benzyl-5-carboxy-2-pyrrolidinone

Procedure

5-oxo-1-(phenylmethyl)proline was prepared in an analogous manner to that described above for the synthesis of 1-(2,2-dimethylpropyl)-5-oxoproline (example 100) but using benzaldehyde in the place of trimethylacetaldehyde.

Sources & evidence

ORD record
ord-38a887ced9484ef6b6f8654471eaf5ea
Source dataset
uspto-grants-2011_11
Patent number
US08048907B2

Reaction notes

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