Methyl morpholine oxide → HCID 86232850, compound

HRID 554304Notes

Reaction equation

HRID 554304 reaction equation
[CH3:1][C:2]1[N:3]([S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)(=[O:16])=[O:15])[C:4]([C:9]2[CH:13]=[CH:12][S:11][CH:10]=2)=[CH:5][C:6]=1[CH2:7][OH:8].C[N+]1([O-])CCOCC1>[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[CH3:1][C:2]1[N:3]([S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)(=[O:15])=[O:16])[C:4]([C:9]2[CH:13]=[CH:12][S:11][CH:10]=2)=[CH:5][C:6]=1[CH:7]=[O:8]

Participants

4

Reactant 2

HCID 82029Methyl morpholine oxideHCID 66924627HCID 66924627, compound

Product 1

HCID 86232850HCID 86232850, compoundYield 101,263.703%

Reagents, catalysts & solvents 1

HCID 178419074HCID 178419074, compoundCatalyst

Procedure

Using [2-methyl-1-(phenylsulfonyl)-5-(3-thienyl)-1H-pyrrol-3-yl]methanol (307 mg), tetra-n-propylammonium perruthenate (26.4 mg), N-methylmorpholine N-oxide (216 mg) and molecular sieves 4A powder (215 mg), a procedure as in Reference Example 6 was performed to give the title compound as a brown oil (yield 309 g, 76%).

Sources & evidence

ORD record
ord-a9549a889f8c45938a1b287bf12d56fe
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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