Methyl morpholine oxide → HCID 86232858, compound

HRID 554306Notes

Reaction equation

HRID 554306 reaction equation
[CH3:1][C:2]1[N:3]([S:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)(=[O:18])=[O:17])[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([CH3:9])[C:6]=1[CH2:7][OH:8].C[N+]1([O-])CCOCC1>[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[CH3:1][C:2]1[N:3]([S:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)(=[O:18])=[O:17])[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([CH3:9])[C:6]=1[CH:7]=[O:8]

Participants

4

Reactant 2

HCID 82029Methyl morpholine oxideHCID 66924715HCID 66924715, compound

Product 1

HCID 86232858HCID 86232858, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 178419074HCID 178419074, compoundCatalyst

Procedure

Using [2,4-dimethyl-5-phenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methanol (0.84 g), tetra-n-propylammonium perruthenate (57.3 mg), N-methylmorpholine N-oxide (437 mg) and molecular sieves 4A powder (422 mg), a procedure as in Reference Example 6 was performed to give the title compound as a brown oil (yield 0.59 g, 71%).

Sources & evidence

ORD record
ord-4baba2b192f44f59873f3aeb6de5d8f3
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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