Sodium hydride → HCID 86232756, compound

HRID 554344Notes

Reaction equation

[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][C:6]=1[CH:7]=[O:8].[H-].[Na+].C1OCCOCCOCCOCCOC1.[N:26]1[CH:31]=[CH:30][CH:29]=[C:28]([S:32](Cl)(=[O:34])=[O:33])[CH:27]=1>>[CH3:1][C:2]1[N:3]([S:32]([C:28]2[CH:27]=[N:26][CH:31]=[CH:30][CH:29]=2)(=[O:34])=[O:33])[CH:4]=[CH:5][C:6]=1[CH:7]=[O:8]

Participants

Reactant 4

HCID 24758Sodium hydride

HCID 3633615-Crown-5

HCID 3164136Pyridine-3-sulfonyl chloride

HCID 53245852-methyl-1H-pyrrole-3-carbaldehyde

Product 1

HCID 86232756HCID 86232756, compound

Procedure

By a similar operation as in Reference Example 146 and using 2-methyl-1H-pyrrole-3-carbaldehyde (1.10 g), sodium hydride (60% in oil, 1.20 g), 15-crown-5 (6.0 mL) and pyridin-3-ylsulfonyl chloride (3.22 g), the title compound was obtained as white crystals (yield 1.10 g, 44%).

Sources & evidence

ORD record: ord-1b4040ea8b244784a73c41d6a3f4df43
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08048909B2

Reaction notes

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