Hydrochloric Acid → HCID 66924986, compound

HRID 554418Notes

Reaction equation

HRID 554418 reaction equation
[F:1][C:2]1[C:3]([CH:22]=O)=[CH:4][N:5]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:15])=[O:14])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.CO.[CH3:26][NH2:27].[BH4-].[Na+].[ClH:30].C(=O)([O-])O.[Na+]>CO>[ClH:30].[F:1][C:2]1[C:3]([CH2:22][NH:27][CH3:26])=[CH:4][N:5]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:15])=[O:14])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 4311764Sodium borohydrideHCID 57454252Monomethylamine methanolHCID 86232728HCID 86232728, compound

Product 1

HCID 66924986HCID 66924986, compoundYield 9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-Fluoro-5-phenyl-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde (10 mg) was dissolved in methanol (5 mL), 40% methylamine methanol solution (236 mg) was added at room temperature, and the mixture was stirred for 30 min. Sodium borohydride (12 mg) was added at room temperature, and the 5 mixture was stirred for 10 min. 1 mol/L Hydrochloric acid (20 mL) was added, and the mixture was stirred for 5 min. The reaction mixture was alkalized with a saturated aqueous sodium hydrogencarbonate solution and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was dissolved in ethyl acetate (5 mL). A 4 mol/L hydrogen chloride-ethyl acetate solution (1 mL) was added, and the mixture was concentrated under reduced pressure. The residue was crystallized from ethyl acetate to give the title compound as colorless crystals (yield 1 mg, 9%).

Workup

  1. stirringthe 5 mixture was stirred for 10 min
  2. stirringthe mixture was stirred for 5 min
  3. extractionextracted with ethyl acetate
  4. washThe extract was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated under reduced pressure
  7. dissolutionThe residue was dissolved in ethyl acetate (5 mL)
  8. additionA 4 mol/L hydrogen chloride-ethyl acetate solution (1 mL) was added
  9. concentrationthe mixture was concentrated under reduced pressure
  10. customThe residue was crystallized from ethyl acetate

Sources & evidence

ORD record
ord-3d622bf0a360461899e5d133b363d7b5
Source dataset
uspto-grants-2011_11
Patent number
US08048909B2

Reaction notes

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