2,2,2-Trifluoroethanol → HCID 15578587, compound

Temperature

0 °C

2,2,2-Trifluoroethanol (15 ml, 0.15 mol) and triethylamine (4.5 ml, 32.12 mmol) were added to 30 ml, of dichloromethane, and cooled to 0° C. After 10 min, 2.94 ml of 3-bromopropionyl chloride (29.2 mmol) was added dropwise thereto. The mixture was warmed to room temperature and stirred for 5 hrs. After the reaction was terminated by addition of water, the mixture was extracted with ethyl acetate, and the solvent was evaporated under a reduced pressure. The solid impurities were removed by filtration to obtain the title compound as a liquid (3.53 g).

1. temperatureThe mixture was warmed to room temperature
2. customAfter the reaction was terminated by addition of water
3. extractionthe mixture was extracted with ethyl acetate
4. customthe solvent was evaporated under a reduced pressure
5. customThe solid impurities were removed by filtration

ORD record

ord-68c687adcd5a434cb985deb99b773eff

Source dataset

uspto-grants-2011_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08048996B2