反应详情

To a solution of (2-benzyloxyphenyl)-(3-methoxyphenyl)methanol (1.68 g, 5.24 mmol) in methanol (50 ml), a 20% palladium hydroxide catalyst (168 mg) was added and furthermore 36% HCl (0.2 mL) was added thereto. The mixture was stirred under a hydrogen atmosphere for 24 hours, and then the catalyst was filtered off. The solvent was distilled under reduced pressure, and the obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:4)] to obtain the title compound (1.29 g, 100%).

1. filtrationthe catalyst was filtered off
2. distillationThe solvent was distilled under reduced pressure
3. customthe obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:4)]