反应详情

To a solution of (2-benzyloxyphenyl)-(3-fluorophenyl)methanol (2.54 g, 7.51 mmol) in methanol (30 ml), a 20% palladium hydroxide catalyst (300 mg) was added and furthermore 2N—HCl (0.3 mL) was added thereto. The mixture solution was stirred under a hydrogen atmosphere for five days, and then the catalyst was filtered off. The solvent was distilled under reduced pressure, and the obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:10)] to obtain the title compound (620 mg, 42%).

1. filtrationthe catalyst was filtered off
2. distillationThe solvent was distilled under reduced pressure
3. customthe obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:10)]