反应详情

To a solution of (2-benzyloxy-6-methoxyphenyl)-(4-methoxyphenyl)-methanol (2.13 g, 6.08 mmol) in methanol (50 mL), a 20% palladium hydroxide catalyst (0.32 g) was added and furthermore 2N—HCl (1.8 mL) was added thereto. The reaction mixture was stirred under a hydrogen atmosphere for 24 hours, and then the catalyst was filtered off. The solvent was distilled under reduced pressure and the obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:4)] to obtain the title compound (1.31 g, 89%).

1. filtrationthe catalyst was filtered off
2. distillationThe solvent was distilled under reduced pressure
3. customthe obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:4)]