Hydrochloric Acid → HCID 131729246, compound

HRID 554607Notes

Reaction equation

HRID 554607 reaction equation
[CH3:1][O:2][C:3](=[O:32])[CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][C:12]=2[CH2:21][N:22](C(OC(C)(C)C)=O)[CH2:23][CH3:24])[CH:10]=1.[ClH:33]>C(Cl)Cl.O1CCOCC1>[ClH:33].[ClH:33].[CH3:1][O:2][C:3](=[O:32])[CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:18])([F:19])[F:20])=[CH:13][C:12]=2[CH2:21][NH:22][CH2:23][CH3:24])[CH:10]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67212420(5-{2-[(N-tert-butoxycarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid methyl ester

Product 1

HCID 131729246HCID 131729246, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To (5-{2-[(N-tert-butoxycarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid methyl ester (0.742 g, 1.6 mmol) in CH2Cl2 (3 mL) was added 4N HCl in 1,4-dioxane (4 mL), and the reaction was stirred at room temperature until no starting material was seen by analytical LCMS. The mixture was then concentrated to give [5-(2-ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid methyl ester, dihydrochloride.

Workup

  1. concentrationThe mixture was then concentrated

Sources & evidence

ORD record
ord-f3f944e884ec4111af9e2a5f65905025
Source dataset
uspto-grants-2011_11
Patent number
US08049015B2

Reaction notes

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