Diethyl Malonate → HCID 178513876, compound

HRID 554664Notes

Reaction equation

HRID 554664 reaction equation
[C:1]([O:9]CC)(=O)[CH2:2][C:3]([O:5]CC)=O.[CH2:12]([C:16]([NH2:18])=[O:17])[C:13]([NH2:15])=[NH:14].Cl.[O-]CC.[Na+]>CCO>[OH:9][C:1]1[CH:2]=[C:3]([OH:5])[N:15]=[C:13]([CH2:12][C:16]([NH2:18])=[O:17])[N:14]=1

Participants

5

Reactant 3

HCID 7761Diethyl MalonateHCID 2723922Sodium ethoxideHCID 3084595Amidinomalonamide hydrochloride

Product 1

HCID 178513876HCID 178513876, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Diethyl malonate and malonamamidine hydrochloride were combined in EtOH (50 mL) with stirring. Sodium ethoxide was added dropwise via addition funnel over 10 minutes. The reaction was stirred overnight at room temperature to give 2-(4,6-dihydroxy-pyrimidin-2-yl)-acetamide.

Workup

  1. stirringThe reaction was stirred overnight at room temperature

Sources & evidence

ORD record
ord-22a9ce536447482fbeaafc79bdf93cc8
Source dataset
uspto-grants-2011_11
Patent number
US08049015B2

Reaction notes

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