1,2-Dichloroethane → HCID 11360779, compound

HRID 555392Notes

Reaction equation

HRID 555392 reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6]C=[CH:4][C:3]=1C.[C:10]([C:14]1[CH:29]=[CH:28][CH:27]=[CH:26][C:15]=1[O:16][C:17]1[C:22]([N:23]=[C:24]=S)=[CH:21][CH:20]=[CH:19][N:18]=1)([CH3:13])([CH3:12])[CH3:11].Cl[CH2:31][CH2:32]Cl>>[C:10]([C:14]1[CH:29]=[CH:28][CH:27]=[CH:26][C:15]=1[O:16][C:17]1[C:22]([NH:23][C:24]2[NH:8][C:7]3[CH:6]=[C:31]([CH3:32])[CH:4]=[CH:3][C:2]=3[N:1]=2)=[CH:21][CH:20]=[CH:19][N:18]=1)([CH3:13])([CH3:12])[CH3:11]

Participants

4

Reactant 3

HCID 111,2-DichloroethaneHCID 175932,3-DiaminotolueneHCID 59857388HCID 59857388, compound

Product 1

HCID 11360779HCID 11360779, compound

Procedure

To a solution of 2,3-diamino toluene (45 mg, 0.368 mmol) in DCE (2 mL) was slowly added 1c (50 mg, 0.176 mmol). The reaction was stirred 18 h at rt and concentrated. The crude mixture containing 1d and 1d′ was used in the next step without further purification. [M+H]+=407.4.

Workup

  1. concentrationconcentrated
  2. additionThe crude mixture containing 1d and 1d′
  3. customwas used in the next step without further purification

Sources & evidence

ORD record
ord-19ebefdb29624e83b57be6434cc4e97d
Source dataset
uspto-grants-2011_11
Patent number
US08053450B2

Reaction notes

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