4-Tert-butylbenzene-1,2-diamine → HCID 11441710, compound

HRID 555398Notes

Reaction equation

HRID 555398 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[C:7]([NH2:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[N:13]([C:16]1[C:17]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=2)=[N:18][CH:19]=[CH:20][CH:21]=1)=[C:14]=S>ClCCCl>[C:1]([C:5]1[CH:10]=[CH:9][C:8]2[N:11]=[C:14]([NH:13][C:16]3[C:17]([O:22][C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:30])[F:31])[CH:24]=4)=[N:18][CH:19]=[CH:20][CH:21]=3)[NH:12][C:7]=2[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 4327084-Tert-butylbenzene-1,2-diamineHCID 21487087HCID 21487087, compound

Product 1

HCID 11441710HCID 11441710, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

To a solution of 4-(tert-butyl)-1,2-diaminobenzene (20 mg, 0.12 mmol) in DCE (1 mL) was slowly added 3c (19 mg, 0.06 mmol). The reaction was stirred 18 h at rt and concentrated. The crude mixture containing 3d and 3d′ was used in the next step without further purification.

Workup

  1. concentrationconcentrated
  2. additionThe crude mixture containing 3d and 3d′
  3. customwas used in the next step without further purification

Sources & evidence

ORD record
ord-5fc5bb685c7147248ab136c5e159944b
Source dataset
uspto-grants-2011_11
Patent number
US08053450B2

Reaction notes

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