反应详情

温度

80 °C

First 17.9 g of potassium carbonate and then 28.14 g of 2-(2-chloroethyl)-toluene-4-sulfonate are added, with stirring, to a solution of 17.4 g of 3-hydroxy-pyrid-2-ylsulfonamide in 240 ml of dimethylacetamide. The reaction mixture is stirred for 1.5 hours at 80° C. and then cooled and filtered. The filtration residue is washed with acetonitrile. The filtrate and the washing liquid are adjusted to pH 5-6 with trifluoroacetic acid, filtered and concentrated using a rotary evaporator. For purification the residue is chromatographed on a silica gel column using ethyl acetate/n-hexane 4/1. Removal of the eluant by evaporation yields 14.42 g of the above sulfonamide in the form of colourless crystals which melt at 136°-138° C.

1. temperaturecooled
2. filtrationfiltered
3. washThe filtration residue is washed with acetonitrile
4. filtrationfiltered
5. concentrationconcentrated
6. customa rotary evaporator
7. customFor purification the residue
8. customis chromatographed on a silica gel column
9. customRemoval of the eluant
10. customby evaporation