反应详情

To 2-benzyl-5,5′-dimethyl-2′-phenyl-2H,2′H-[3,4′]bipyrazolyl-3′-ol (Example 36, 0.200 g, 0.58 mmol) in DMF add cesium carbonate (0.944 g, 2.90 mmol), and then iodomethane (0.823 g, 5.8 mmol). Stir this mixture at room temperature overnight. Dilute the reaction mixture with ethyl acetate, wash with water (25 ml×5) and dry (sodium sulfate). Chromatograph on silica gel, eluting with 50-100% ethyl acetate/heptane to provide 0.045 g of the title compound.

1. washwash with water (25 ml×5)
2. dry with materialdry (sodium sulfate)
3. washChromatograph on silica gel, eluting with 50-100% ethyl acetate/heptane