N,N-Dimethylethylenediamine → HCID 63082312, compound

HRID 555722Notes

Reaction equation

HRID 555722 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4](F)[CH:3]=1.[CH3:11][N:12]([CH3:16])[CH2:13][CH2:14][NH2:15]>>[NH2:7][CH2:6][C:5]1[CH:8]=[CH:9][C:2]([Cl:1])=[CH:3][C:4]=1[NH:15][CH2:14][CH2:13][N:12]([CH3:16])[CH3:11]

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 936554-Chloro-2-fluorobenzonitrile

Product 1

HCID 63082312HCID 63082312, compound

Procedure

The title compound is synthesized by coupling followed by reduction of 4-chloro-2-fluoro-benzonitrile and 2-dimethylamino-ethylamine analogously to the preparation of Intermediate 113.1 as a colorless oil; 1HNMR (CDCl3) δ 9.20 (bs, 1H), 7.18-7.10 (m, 2H), 6.95 (d, 1H), 4.60 (s, 2H), 3.80 (s, 2H), 3.25-3.05 (m, 4H), 2.25 (s, 6H); HPLC: AtRet=1.26 min.

Workup

  1. customAtRet=1.26 min.

Sources & evidence

ORD record
ord-dacc17d885e44469843e1925fd2d3b15
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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