反应详情

To a mixture of triclosan (7.53 grams, 26 mmol) and triethylamine (8.2 grams, 81 mmol) in acetone (50 mL) at 0° C. was added benzyloxy acetyl chloride (10 grams, 54.2 mmol) drop wise. The reaction mixture was stirred at room temperature for 18 hours. Solids were filtered off and poured onto cold water (100 mL). Crude 4 was extracted into chloroform, washed with 5% sodium bicarbonate solution (2×50 mL), and water (2×50 mL). The chloroform layer was dried over sodium sulphate and distilled off to get crude 4.

1. filtrationSolids were filtered off
2. additionpoured onto cold water (100 mL)
3. extractionCrude 4 was extracted into chloroform
4. washwashed with 5% sodium bicarbonate solution (2×50 mL), and water (2×50 mL)
5. dry with materialThe chloroform layer was dried over sodium sulphate
6. distillationdistilled off
7. customto get crude 4