Trifluoroacetic acid → HCID 66992094, compound

HRID 556285Notes

Reaction equation

HRID 556285 reaction equation
C([O:5][C:6](=[O:27])[CH:7]=[CH:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]=[CH:16][C:17](=[O:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:11][C:10]=1[O:25][CH3:26])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:26][O:25][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][C:17](=[O:24])[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:13]=[CH:14][C:9]=1[CH:8]=[CH:7][C:6]([OH:27])=[O:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66991737HCID 66991737, compound

Product 1

HCID 66992094HCID 66992094, compoundYield 100.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-[2-methoxy-4-(3-oxo-3-phenyl-propenyl)-phenyl]-acrylic acid tert-butyl ester (635 mg, 1.74 mmol) was dissolved in DCM (12 ml) and TFA (3 ml) was added to the resulting solution. After stirring for 2 h at room temperature the solvent was removed under vacuo giving 541 mg of 3-[2-methoxy-4-(3-oxo-3-phenyl-propenyl)-phenyl]-acrylic acid as yellow powder.

Workup

  1. customwas removed under vacuo

Sources & evidence

ORD record
ord-a4e30743e99e4a598e5ee955199a6d9e
Source dataset
uspto-grants-2011_11
Patent number
US08058273B2

Reaction notes

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