HCID 66991881, compound → HCID 66991983, compound

HRID 556286Notes

Reaction equation

HRID 556286 reaction equation
C([O:5][C:6](=[O:25])[CH:7]=[CH:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]=[CH:16][C:17](=[O:24])[C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)=[CH:11][CH:10]=1)(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[O:24]=[C:17]([C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)[CH:16]=[CH:15][C:12]1[CH:11]=[CH:10][C:9]([CH:8]=[CH:7][C:6]([OH:25])=[O:5])=[CH:14][CH:13]=1

Participants

4

Reactant 1

HCID 66991881HCID 66991881, compound

Product 1

HCID 66991983HCID 66991983, compoundYield 105.8%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

3-[4-(3-oxo-3-pyridin-3-yl-propenyl)-phenyl]-acrylic acid tert-butyl ester (680 mg, 2.03 mmol) was dissolved in DCM (15 ml) and TFA (5 ml). The resulting solution was stirred at room temperature for 4 h then the solvent was removed under vacuo giving 600 mg of 3-[4-(3-oxo-3-pyridin-3-yl-propenyl)-phenyl]-acrylic acid as trifluoro acetate salt.

Workup

  1. customthe solvent was removed under vacuo

Sources & evidence

ORD record
ord-bd48a239e62940be8e0269b2b49c1724
Source dataset
uspto-grants-2011_11
Patent number
US08058273B2

Reaction notes

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