Hydrochloric Acid → (S)-methyl 2-amino-4-bromobutanoate

HRID 556394Notes

Reaction equation

HRID 556394 reaction equation
Br.[NH2:2][C@@H:3]([CH2:7][CH2:8][Br:9])[C:4]([OH:6])=[O:5].Cl.[CH3:11]O>>[CH3:11][O:5][C:4](=[O:6])[C@@H:3]([NH2:2])[CH2:7][CH2:8][Br:9]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2733672(S)-(+)-2-Amino-4-bromobutyric Acid Hydrobromide

Product 1

HCID 1512645(S)-methyl 2-amino-4-bromobutanoate

Procedure

A solution of (5)-(+)-2-amino-4-bromobutyric acid hydrobromide salt (5 g) in a solution of 3M HCl in MeOH (57 mL) was refluxed for 20 h. The reaction mixture was evaporated off to afford after HV drying the desired compound as a brown oil (3.97 g).

Workup

  1. customThe reaction mixture was evaporated off
  2. customto afford after HV
  3. dry with materialdrying the desired compound as a brown oil (3.97 g)

Sources & evidence

ORD record
ord-f70935b2fcb34a9283e40c5912fa8038
Source dataset
uspto-grants-2011_11
Patent number
US08058263B2

Reaction notes

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