Piperazine → HCID 59755095, compound

HRID 556398Notes

Reaction equation

HRID 556398 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:21][C:9]3[N:10]=[C:11]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[N:12]=[C:13]([CH3:14])[C:8]=3[C:6]=2[N:7]=1.[NH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>O1CCCC1>[Cl:1][C:2]1[N:3]=[C:4]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[C:5]2[S:21][C:9]3[N:10]=[C:11]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[N:12]=[C:13]([CH3:14])[C:8]=3[C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 59755113HCID 59755113, compound

Product 1

HCID 59755095HCID 59755095, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3.0 g (8.6 mmol) 2,4-dichloro-9-methyl-7-phenyl-thieno[2,3-d:4,5-d′]dipyrimidine and 2.0 g (23.2 mmol) piperazine are added by stirring to 40 ml tetrahydrofuran at room temperature for 6 h. Thereafter, the solvent is removed, the residue is suspended in water, sucked off, washed with 40 ml water and dried. 1.5 g (44%) 2-chloro-9-methyl-4-piperazin-1-yl-7-phenyl-thieno[2,3-d:4,5-d′]dipyrimidine is obtained.

Workup

  1. customThereafter, the solvent is removed
  2. washwashed with 40 ml water
  3. customdried

Sources & evidence

ORD record
ord-8de1d8fe151c4b4ea626239c44e90f6f
Source dataset
uspto-grants-2011_11
Patent number
US08058285B2

Reaction notes

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