Piperazine → HCID 11524621, compound

HRID 556414Notes

Reaction equation

HRID 556414 reaction equation
Cl[C:2]1[C:3]2[S:13][C:12]3[N:14]=[C:15]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:16]=[C:17]([CH3:18])[C:11]=3[C:4]=2[N:5]=[C:6]([S:8][CH2:9][CH3:10])[N:7]=1.[NH:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>O1CCCC1>[CH2:9]([S:8][C:6]1[N:7]=[C:2]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[C:3]2[S:13][C:12]3[N:14]=[C:15]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:16]=[C:17]([CH3:18])[C:11]=3[C:4]=2[N:5]=1)[CH3:10]

Participants

4

Reactant 2

HCID 4837PiperazineHCID 59755129HCID 59755129, compound

Product 1

HCID 11524621HCID 11524621, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.63 g (1.7 mmol) 4-chloro-2-ethylthio-9-methyl-7-phenyl-pyrido-[3′,2′:4,5]thieno[3,2-d]pyrimidine is stirred with 0.29 g (3.4 mmol) piperazine in 10 ml tetrahydrofuran at room temperature for 1 h. The precipitate is sucked off, washed with some water and suck dried. Thereafter, the precipitate is suspended in about 300 ml dichloromethane, fully stirred, filtrated and the solvent of the filtrate is removed. 0.67 g (93%) of the title substance is obtained. ESI-MS [m/z]: 422, melting point: 150-154° C.

Workup

  1. washwashed with some water and suck
  2. customdried
  3. filtrationfiltrated
  4. customthe solvent of the filtrate is removed
  5. custom0.67 g (93%) of the title substance is obtained

Sources & evidence

ORD record
ord-4e56f88b4a5d4951921ce94f6e653d45
Source dataset
uspto-grants-2011_11
Patent number
US08058285B2

Reaction notes

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