Piperazine → HCID 11641246, compound

HRID 556417Notes

Reaction equation

HRID 556417 reaction equation
Cl[C:2]1[C:3]2[S:13][C:12]3[N:14]=[C:15]([C:19]4[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH3:28])[CH:20]=4)[CH:16]=[C:17]([CH3:18])[C:11]=3[C:4]=2[N:5]=[C:6]([CH2:8][CH2:9][CH3:10])[N:7]=1.[NH:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>O1CCCC1>[CH3:28][O:27][C:21]1[CH:20]=[C:19]([C:15]2[CH:16]=[C:17]([CH3:18])[C:11]3[C:4]4[N:5]=[C:6]([CH2:8][CH2:9][CH3:10])[N:7]=[C:2]([N:29]5[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]5)[C:3]=4[S:13][C:12]=3[N:14]=2)[CH:24]=[CH:23][C:22]=1[O:25][CH3:26]

Participants

4

Reactant 2

HCID 4837PiperazineHCID 59755071HCID 59755071, compound

Product 1

HCID 11641246HCID 11641246, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.42 g (1.0 mmol) 4-chloro-7-(3,4-dimethoxyphenyl)-9-methyl-2-propyl-pyrido-[3′,2′:4,5]thieno[3,2-d]pyrimidine and 0.37 g (4.3 mmol) piperazine in 8 ml tetrahydrofuran are stirred at room temperature for 4 h. Having removed the solvent, the residue is suspended in 10 ml water and sucked off. The residue is suspended in about 50 ml dichloromethane and filtrated. The filtrate is washed with a total of 30 ml water, dried on sodium sulfate and the solvent is removed. The residue is recrystallized from ethyl acetate. 0.17 g (37%) of the title substance is obtained.

Workup

  1. customHaving removed the solvent
  2. filtrationfiltrated
  3. washThe filtrate is washed with a total of 30 ml water
  4. customdried on sodium sulfate
  5. customthe solvent is removed
  6. customThe residue is recrystallized from ethyl acetate
  7. custom0.17 g (37%) of the title substance is obtained

Sources & evidence

ORD record
ord-eafa36c562244da79123b619d1f4feb4
Source dataset
uspto-grants-2011_11
Patent number
US08058285B2

Reaction notes

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