Hydrazine hydrate (1:1) → HCID 178507390, compound

HRID 556439Notes

Reaction equation

HRID 556439 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10](Cl)[N:9]=2)=[CH:4][CH:3]=1.O.[NH2:18][NH2:19]>C(O)CC>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[NH:18][N:19]=[C:12]([NH2:13])[C:11]3=[CH:14][CH:15]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 597666616-(4-Aminophenyl)-2-chloronicotinonitrile

Product 1

HCID 178507390HCID 178507390, compoundYield 98.4%

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Conditions

Temperature
130 °C

Procedure

In an appropriately sized microwave reactor, 0.97 mmol (222 mg) of 6-(4-aminophenyl)-2-chloronicotinonitrile is suspended in 3.3 ml of 1-propanol. 0.28 ml (0.290 g, 5.80 mmol, 6 eq.) of hydrazine hydrate is added. The suspension is heated for 45 minutes at 130° C. in a microwave oven. The mixture is filtered and the solid is dried so as to obtain a green solid (215 mg).

Workup

  1. filtrationThe mixture is filtered
  2. customthe solid is dried so as

Sources & evidence

ORD record
ord-24b5c284da7049d8b6aead65862e563a
Source dataset
uspto-grants-2011_11
Patent number
US08058290B2

Reaction notes

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