Dimethylamine → HCID 59639578, compound

HRID 556644Notes

Reaction equation

[CH3:1][NH:2][CH3:3].C[Al](C)C.[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=1[N:16]1[C:21]2[N:22]=[C:23]([NH:34][CH2:35][C:36]([O:38]C)=O)[N:24]=[C:25]([C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=3[CH3:33])[C:20]=2[CH:19]=[CH:18][C:17]1=[O:40]>>[F:15][C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([F:8])[C:10]=1[N:16]1[C:21]2[N:22]=[C:23]([NH:34][CH2:35][C:36]([N:2]([CH3:3])[CH3:1])=[O:38])[N:24]=[C:25]([C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=3[CH3:33])[C:20]=2[CH:19]=[CH:18][C:17]1=[O:40]

Participants

Reactant 3

HCID 674Dimethylamine

HCID 16682925Trimethylaluminum

HCID 59639612HCID 59639612, compound

Product 1

HCID 59639578HCID 59639578, compoundYield 54.5%

Procedure

Following the general procedure outlined in Example 193, dimethylamine (1.1 mL, 2.2 mmol), trimethylaluminum (1.1 mL, 2.2 mmol) and the product of Example 190 (100 mg, 0.22 mmol) were reacted to give the desired product 56 mg (54%). LC-MS: 468.2 (MH+, m/z), 2.00 (Rt, min).

Sources & evidence

ORD record: ord-88e0926b81b14dcd90a81d106177ff54
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08058282B2

Reaction notes

Loading…