2-Methoxyethylamine → HCID 59639571, compound

HRID 556645Notes

Reaction equation

HRID 556645 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].C[Al](C)C.[F:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:12]=1[N:18]1[C:23]2[N:24]=[C:25]([NH:36][CH2:37][C:38](OC)=[O:39])[N:26]=[C:27]([C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][C:29]=3[CH3:35])[C:22]=2[CH:21]=[CH:20][C:19]1=[O:42]>>[F:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:12]=1[N:18]1[C:23]2[N:24]=[C:25]([NH:36][CH2:37][C:38]([NH:5][CH2:4][CH2:3][O:2][CH3:1])=[O:39])[N:26]=[C:27]([C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][C:29]=3[CH3:35])[C:22]=2[CH:21]=[CH:20][C:19]1=[O:42]

Participants

4

Reactant 3

HCID 80182-MethoxyethylamineHCID 16682925TrimethylaluminumHCID 59639612HCID 59639612, compound

Product 1

HCID 59639571HCID 59639571, compoundYield 66.2%

Procedure

Following the general procedure outlined in Example 193, 2-methoxy-ethylamine (0.17 mL, 2.2 mmol), trimethylaluminum (1.1 mL, 2.2 mmol) and the product of Example 190 (200 mg, 0.44 mmol) were reacted to give the desired product 145 mg (66%). LC-MS: 498.2 (MH+, m/z), 1.90 (Rt, min).

Sources & evidence

ORD record
ord-67f71143165d4d6c93b5a241a633fb78
Source dataset
uspto-grants-2011_11
Patent number
US08058282B2

Reaction notes

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