Hydrogen Bromide → AZD-3199 dihydrobromide

HRID 556716Notes

Reaction equation

HRID 556716 reaction equation
[CH2:1]([N:3]([CH2:40][CH3:41])[CH2:4][CH2:5][N:6]([CH2:24][CH2:25][NH:26][CH2:27][CH2:28][C:29]1[C:37]2[S:36][C:35](=[O:38])[NH:34][C:33]=2[C:32]([OH:39])=[CH:31][CH:30]=1)[C:7](=[O:23])[CH2:8][CH2:9][O:10][CH2:11][CH2:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1)[CH3:2].[BrH:42]>C(O)C>[BrH:42].[BrH:42].[CH2:40]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][N:6]([CH2:24][CH2:25][NH:26][CH2:27][CH2:28][C:29]1[C:37]2[S:36][C:35](=[O:38])[NH:34][C:33]=2[C:32]([OH:39])=[CH:31][CH:30]=1)[C:7](=[O:23])[CH2:8][CH2:9][O:10][CH2:11][CH2:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1)[CH3:41]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 16035068Azd-3199

Product 1

HCID 25031637AZD-3199 dihydrobromide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-[2-(Diethylamino)ethyl]-N-(2-{[2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl]amino}ethyl)-3-[2-(1-naphthyl)ethoxy]propanamide (0.052 g) was dissolved in ethanol (1.5 mL) and treated with 48% hydrobromic acid (21 μl). The white solid dihydrobromide salt (0.058 g) was collected by filtration.

Workup

  1. filtrationThe white solid dihydrobromide salt (0.058 g) was collected by filtration

Sources & evidence

ORD record
ord-567d07093cb64a0b8aad4dfedf69730b
Source dataset
uspto-grants-2011_11
Patent number
US08058294B2

Reaction notes

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