Sodium hydride → tert-Butyl 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylate

HRID 556946Notes

Reaction equation

[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([C:8]#[N:9])=O)=[CH:4][CH:3]=1.[C:12]([O:16][C:17](=[O:25])[N:18]([CH2:22][CH2:23]Cl)[CH2:19][CH2:20]Cl)([CH3:15])([CH3:14])[CH3:13].[H-].[Na+]>CN(C)C=O>[C:12]([O:16][C:17]([N:18]1[CH2:22][CH2:23][C:6]([C:5]2[CH:10]=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=2)([C:8]#[N:9])[CH2:20][CH2:19]1)=[O:25])([CH3:15])([CH3:14])[CH3:13]

Participants

Conditions

Temperature: 60 °C

Procedure

To 1.26 g (8.37 mmol) 4-chloro-benzoylcyanide was added bis-(2-chloroethyl)-carbamic acid tert-butyl ester (2.02 g, 8.37 mmol) in 25 ml N,N-dimethylformamide. The resulting mixture was stirred and cooled in an ice bath, then sodium hydride (60% suspension in mineral oil) (1.1 g, 42 mmol) was added portionwise. The reaction was brought to room temperature and then heated in an oil bath at 60° C. for 16 hours. The reaction mixture was quenched by addition of ice water and the aqueous phase was extracted with ethyl acetate. The combined organic layers were washed twice with water, once with brine, dried with magnesium sulfate and concentrated in vacuo. The residual brown oil was purified by silica gel chromatography eluting with hexane-ethyl:acetate (9:1) to give the title compound (1.44 g, 54%).

Workup

temperaturecooled in an ice bath
customwas brought to room temperature
customThe reaction mixture was quenched by addition of ice water
extractionthe aqueous phase was extracted with ethyl acetate
washThe combined organic layers were washed twice with water, once with brine
dry with materialdried with magnesium sulfate
concentrationconcentrated in vacuo
customThe residual brown oil was purified by silica gel chromatography
washeluting with hexane-ethyl:acetate (9:1)

Sources & evidence

ORD record: ord-fdb508b303544fe3b87547350aaf356a
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08058287B2

Reaction notes

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