Sodium Bicarbonate → 5-Bromoimidazo(1,2-a)pyridine

HRID 557175Notes

Reaction equation

HRID 557175 reaction equation
C(=O)(O)[O-].[Na+].Br.[Br:7][C:8]1[N:13]2[CH:14]=[CH:15][N:16]=[C:12]2[CH:11]=[CH:10][CH:9]=1>C(OCC)(=O)C>[Br:7][C:8]1[N:13]2[CH:14]=[CH:15][N:16]=[C:12]2[CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 179854305-Bromoimidazo[1,2-a]pyridine hydrobromide

Product 1

HCID 130372415-Bromoimidazo(1,2-a)pyridine

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Add saturated sodium bicarbonate (300 ml) to a suspension of 5-bromoimidazo[1,2-a]pyridine hydrobromide (13.0 g, 46.96 mmol) in ethyl acetate. Separate the organic layer and wash it with saturated sodium bicarbonate, dry over magnesium sulfate, and concentrated under reduced pressure to give the title compound as a white solid.

Workup

  1. customSeparate the organic layer
  2. washwash it with saturated sodium bicarbonate
  3. dry with materialdry over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-2c9a5ca248924d83ac3df05ef9d03b9a
Source dataset
uspto-grants-2011_11
Patent number
US08058425B2

Reaction notes

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