反应详情

3-(3-(4-(Pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-yl amine (200 mg) was dissolved in methanol and ethyl acetate, and an aqueous solution of hydrobromic acid (1.16N, 0.45 mL) was added thereto. The solvent was concentrated under a reduced pressure. To the residue was added toluene, and concentrated under a reduced pressure. To the residue were added ethanol and tert-butyl methyl ether, then subjected to ultrasound treatment to be solidified. The solids were filtered to obtain the title compound (210 mg).

1. concentrationThe solvent was concentrated under a reduced pressure
2. additionTo the residue was added toluene
3. concentrationconcentrated under a reduced pressure
4. additionTo the residue were added ethanol and tert-butyl methyl ether
5. filtrationThe solids were filtered