Ethylenediamine → N~1~-(Pyridin-2-yl)ethane-1,2-diamine

HRID 557352Notes

Reaction equation

[CH2:1]([NH2:4])[CH2:2][NH2:3].F[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1>>[N:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[NH:3][CH2:2][CH2:1][NH2:4]

Participants

Reactant 2

HCID 3301Ethylenediamine

HCID 97462-Fluoropyridine

Product 1

HCID 410428N~1~-(Pyridin-2-yl)ethane-1,2-diamine

Procedure

Ethylenediamine (6 g, 0.1 mol) and 2-fluoropyridine (10 g, 0.1 mol) were heated neat at 120° C. overnight. The reaction was cooled and the residue was used in next step without further purification.

Workup

temperatureThe reaction was cooled
customthe residue was used in next step without further purification

Sources & evidence

ORD record: ord-034ce77ba6404c0893cbfef2c3b075fa
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08058445B2

Reaction notes

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