tert-Butanol → tert-Butyl 2-chloro-2-oxoacetate

HRID 55747Notes

Reaction equation

HRID 55747 reaction equation
[C:1](Cl)(=[O:5])[C:2]([Cl:4])=[O:3].[C:7]([OH:11])([CH3:10])([CH3:9])[CH3:8]>CCOCC>[C:7]([O:11][C:1](=[O:5])[C:2]([Cl:4])=[O:3])([CH3:10])([CH3:9])[CH3:8]

Participants

4

Reactant 2

HCID 6386tert-ButanolHCID 65578Oxalyl chloride

Product 1

HCID 11126621tert-Butyl 2-chloro-2-oxoacetate

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Oxalyl chloride (232 μL, 2.8 mmol) and t-butyl alcohol (228 μL) were combined in ether (6.7 mL) under nitrogen at 0° C. The resulting mixture was stirred for 30 minutes at room temperature. The solvent was evaporated under vacuum to form Compound 34.

Workup

  1. customThe solvent was evaporated under vacuum

Sources & evidence

ORD record
ord-d872591027264a99a4c357f08f23f73a
Source dataset
uspto-grants-2016_09
Patent number
US09433598B2

Reaction notes

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