tert-Butyl isothiocyanate → HCID 86595167, compound

HRID 557560Notes

Reaction equation

HRID 557560 reaction equation
NC(N)=S.[C:5]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([NH2:18])=[CH:15][CH:16]=2)[C:11]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([CH3:19])[CH2:10][C:9]1([CH3:27])[CH3:26])(=[O:7])[CH3:6].[C:28]([N:32]=[C:33]=[S:34])([CH3:31])([CH3:30])[CH3:29].C(N(CC)C(C)C)(C)C>O1CCCC1>[C:5]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([NH:18][C:33]([NH:32][C:28]([CH3:31])([CH3:30])[CH3:29])=[S:34])=[CH:15][CH:16]=2)[C:11]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([CH3:19])[CH2:10][C:9]1([CH3:27])[CH3:26])(=[O:7])[CH3:6]

Participants

6

Reactant 4

HCID 11544tert-Butyl isothiocyanateHCID 81531DiisopropylethylamineHCID 2723790ThioureaHCID 28370841-(6-amino-2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)ethanone

Product 1

HCID 86595167HCID 86595167, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Thiourea formation of 1-acetyl-6-amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (10 mg) with tert-butyl isothiocyanate (7.5 mg) and N,N-diisopropylethylamine (22 μl) in tetrahydrofuran (1 ml) was performed according to the method described in example 18.

Sources & evidence

ORD record
ord-91fa3166a94041969d68ab363b160ad6
Source dataset
uspto-grants-2011_11
Patent number
US08058441B2

Reaction notes

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