2-Furancarbonyl chloride → HCID 66992312, compound

HRID 557593Notes

Reaction equation

HRID 557593 reaction equation
[C:1]([C:4]1([CH3:26])[C:9]([NH2:10])=[CH:8][C:7]([C:11](N2C3C(=CC=CC=3)C(C)CC2(C)C)=[O:12])=[CH:6][CH2:5]1)(=[O:3])[CH3:2].[O:27]1[CH:31]=[CH:30][CH:29]=[C:28]1[C:32](Cl)=[O:33].[CH:35]([N:38](CC)[CH:39]([CH3:41])[CH3:40])([CH3:37])[CH3:36]>O1CCCC1>[C:1]([C:4]1([CH3:26])[C:9]([NH:10][C:32]([C:28]2[O:27][CH:31]=[CH:30][CH:29]=2)=[O:33])=[CH:8][CH:7]([C:11]([C:5]2[C:35]([CH3:36])([CH3:37])[NH:38][C:39]3[C:40]([C:6]=2[CH3:7])=[CH:4][CH:1]=[CH:2][CH:41]=3)=[O:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 682422-Furancarbonyl chlorideHCID 81531DiisopropylethylamineHCID 66992168HCID 66992168, compound

Product 1

HCID 66992312HCID 66992312, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Acylation of 1-acetyl-6-amino-4-toloyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (10 mg) with 2-furoyl chloride (8.1 mg) and N,N-diisopropylethylamine (20 μl) in tetrahydrofuran (1 ml) was performed according to the method described in example 6.

Sources & evidence

ORD record
ord-13e711c988664dbf8976fec7c232c922
Source dataset
uspto-grants-2011_11
Patent number
US08058441B2

Reaction notes

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