Diisopropylethylamine → HCID 17962921, compound

HRID 557606Notes

Reaction equation

HRID 557606 reaction equation
[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([NH:14][C:15](=[O:23])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[OH:22])=[CH:11][CH:12]=2)[C:7]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([CH3:24])[CH2:6][C:5]1([CH3:32])[CH3:31])(=[O:3])[CH3:2].[CH3:33][C:34]1[O:38][N:37]=[C:36]([C:39](Cl)=[O:40])[CH:35]=1.C(N(CC)C(C)C)(C)C>O1CCCC1>[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([NH:14][C:15](=[O:23])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[O:22][C:39]([C:36]3[CH:35]=[C:34]([CH3:33])[O:38][N:37]=3)=[O:40])=[CH:11][CH:12]=2)[C:7]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([CH3:24])[CH2:6][C:5]1([CH3:32])[CH3:31])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 27368945-Methylisoxazole-3-carbonyl chlorideHCID 17962902HCID 17962902, compound

Product 1

HCID 17962921HCID 17962921, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Acylation of 1-acetyl-6-(2-hydroxybenzoyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (15 mg) with 5-methylisoxazole-3-carbonyl chloride (10 mg) and N,N-diisopropylethylamine (30 μl) in tetrahydrofuran (1 ml) was performed according to the method described in example 6.

Sources & evidence

ORD record
ord-0337ed2418b4413eba3249a0630dd4a0
Source dataset
uspto-grants-2011_11
Patent number
US08058441B2

Reaction notes

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