Furfuryl Alcohol → HCID 17962908, compound

HRID 557610Notes

Reaction equation

HRID 557610 reaction equation
[CH2:1]([OH:7])[C:2]1[O:6][CH:5]=[CH:4][CH:3]=1.[C:8]([N:11]1[C:20]2[C:15](=[CH:16][C:17]([NH:21][C:22]([CH2:24][C:25](O)=[O:26])=[O:23])=[CH:18][CH:19]=2)[C:14]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)([CH3:28])[CH2:13][C:12]1([CH3:36])[CH3:35])(=[O:10])[CH3:9].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(CC)C(C)C)(C)C>O1CCCC1>[C:8]([N:11]1[C:20]2[C:15](=[CH:16][C:17]([NH:21][C:22]([CH2:24][C:25]([O:7][CH2:1][C:2]3[O:6][CH:5]=[CH:4][CH:3]=3)=[O:26])=[O:23])=[CH:18][CH:19]=2)[C:14]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)([CH3:28])[CH2:13][C:12]1([CH3:36])[CH3:35])(=[O:10])[CH3:9]

Participants

6

Reactant 4

HCID 7361Furfuryl AlcoholHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 17962869HCID 17962869, compound

Product 1

HCID 17962908HCID 17962908, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Condensation of furfuryl alcohol (17 μl) and 1-acetyl-6-(hydroxycarbonylmethylcarbonyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (15 mg) under the agency of HATU (29 mg) and N,N-diisopropylethylamine (33 μl) in tetrahydrofuran (2 ml) was performed according to the method described in example 11.

Sources & evidence

ORD record
ord-cdabe7010aa642b7a669efb4c3c606e0
Source dataset
uspto-grants-2011_11
Patent number
US08058441B2

Reaction notes

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