反应详情

To a solution of cyclohexanone (1.34 g, 13.6 mmol) in toluene at room temperature was added DMF (1.58 mL, 20.5 mmol) and phosphorus oxychloride (1.88 mL, 20.5 mmol). The reaction was stirred overnight at room temperature, and then diluted with H2O and stirred for 30 minutes. 4N Aqueous NaOH (10 mL) was added, and the mixture was extracted with EtOAc. The combined organic layers were washed with saturated aqueous NH4Cl, dried over MgSO4, filtered, and concentrated to give the title compound.

1. stirringstirred for 30 minutes
2. extractionthe mixture was extracted with EtOAc
3. washThe combined organic layers were washed with saturated aqueous NH4Cl
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated