Hydrochloric Acid → HCID 66999864, compound

HRID 558175Notes

Reaction equation

HRID 558175 reaction equation
C(OC([NH:8][C:9]1[CH:14]=[C:13]([CH2:15][S:16][C:17]2[C:22]([C:23]3[O:27][C:26]([NH:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[N:25][N:24]=3)=[CH:21][CH:20]=[CH:19][N:18]=2)[CH:12]=[CH:11][N:10]=1)=O)(C)(C)C.[ClH:35]>O1CCOCC1>[ClH:35].[NH2:8][C:9]1[CH:14]=[C:13]([CH2:15][S:16][C:17]2[C:22]([C:23]3[O:27][C:26]([NH:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[N:25][N:24]=3)=[CH:21][CH:20]=[CH:19][N:18]=2)[CH:12]=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 24996813HCID 24996813, compound

Product 1

HCID 66999864HCID 66999864, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 5-(2-(2-t-butoxycarbonylaminopyridin-4-yl) methylthiopyridin-3-yl)-N-phenyl-1,3,4-oxadiazol-2-amine (140 mg, 0.30 mmol; Compound 1-(7)) in dioxane (1.0 mL) was added a 4M dioxane solution of hydrogen chloride (1.0 mL, 4.0 mmol) at room temperature and then the mixture was stirred over night. The precipitated solid was filtered off to give 130 mg (quantitative) of the titled compound as a colorless solid.

Workup

  1. filtrationThe precipitated solid was filtered off

Sources & evidence

ORD record
ord-2829d0c8885046b7bb3c1a87df8702c3
Source dataset
uspto-grants-2011_11
Patent number
US08063034B2

Reaction notes

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