Formic Acid → 3-Bromo-4-methylpyridin-2-ol

HRID 558467Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 558467
[Br:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[CH:6][C:7]=1[CH3:8].C(O)=[O:11].O>>[Br:1][C:2]1[C:3](=[O:11])[NH:4][CH:5]=[CH:6][C:7]=1[CH3:8]

Komponenten

4

Edukt 3

HCID 284Formic AcidHCID 962WaterHCID 404251193-Bromo-2-chloro-4-methylpyridine

Produkt 1

HCID 134638133-Bromo-4-methylpyridin-2-ol

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

To a resealable pressure vessel charged with 3-bromo-2-chloro-4-picoline (1.200 g, 5.81 mmol) was added formic acid (13.1 ml, 348 mmol) and water (4.00 ml, 222 mmol). The tube was sealed and the solution heated to 120° C. After 72 hrs, the solution was cooled to RT and concentrated in vacuo. The residue was purified by reverse phase chromatography (neutral) to afford 3-bromo-4-methylpyridin-2(1H)-one as a white solid. M+H+=188.0.

Aufarbeitung

  1. customThe tube was sealed
  2. temperaturethe solution was cooled to RT
  3. concentrationconcentrated in vacuo
  4. customThe residue was purified by reverse phase chromatography (neutral)

Quellen und Nachweise

ORD-Eintrag
ord-47f0014f41424e53bb949261e0874928
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063055B2

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