反应详情

A solution of 5-bromo-2-fluoropyridine (2.5 g, 14 mmol) in THF (50 mL) was stirred with a solution of methylamine in THF (c=2 mol/L) (35 mL, 70 mmol) at 23° C. for 16 h. Water was added and the mixture was extracted with ether, the organic layer was dried over Na2SO4. Removal of the solvent in vacuum left a residue which was purified by silica gel column chromatography with heptane/ether, followed by trituration with heptane to give the title compound as a white solid (630 mg, 24%). MS (ISP) 187.1 [(M+H)+], 189.2 [(M+2+H)+].

1. extractionthe mixture was extracted with ether
2. dry with materialthe organic layer was dried over Na2SO4
3. customRemoval of the solvent in vacuum
4. waitleft a residue which
5. customwas purified by silica gel column chromatography with heptane/ether