反应详情

To a solution of 6-fluoro-1,3,4,5-tetrahydrobenzo[b][1,4]diazepin-2-one from Example 1B (220 mg, 1.2 mmol) in DMF (4 ml) was added sodium hydride (60%, 48 mg, 1.2 mmol) while cooling in an ice/water bath. The mixture was allowed to warm to room temperature and was stirred for 10 min. Tert-butyl bromoacetate (190 μl, 1.2 mmol) was added and the mixture was stirred for 18 h. Brine was added and the mixture was evaporated in vacuo. The residue was partitioned between EtOAc and brine and the organic layer was reduced in vacuo. The residue was purified by flash chromatography on silica (eluant: EtOAc:pet ether 60:40); yield 240 mg, 67%.

1. temperaturewhile cooling in an ice/water bath
2. stirringthe mixture was stirred for 18 h
3. customthe mixture was evaporated in vacuo
4. customThe residue was partitioned between EtOAc and brine
5. customThe residue was purified by flash chromatography on silica (eluant: EtOAc:pet ether 60:40)