反应详情

To a solution of 2-bromoaniline (137 mg, 0.80 mmol) in THF (4.0 ml) was added 2-furanboronic acid (89 mg, 0.80 mmol), tetrakis-(triphenylphosphine)palladium (0) (92 mg, 0.08 mmol) and sodium carbonate solution (2M, 2.0 ml, 4.0 mmol). The mixture was heated in a sealed tube using a microwave reactor (20 W) at 130° C. for 25 min. This procedure was carried out 5 times and the reaction mixtures were combined. The mixture was separated and the aqueous layer extracted with EtOAc. The combined organic layers were dried and evaporated in vacuo. The residue was purified by flash chromatography on silica (eluant pet. ether:EtOAc 85:15) to give a brown oil; yield 211 mg, 33%.

1. temperatureThe mixture was heated in a sealed tube
2. customat 130° C.
3. customfor 25 min
4. customthe reaction mixtures
5. customThe mixture was separated
6. extractionthe aqueous layer extracted with EtOAc
7. customThe combined organic layers were dried
8. customevaporated in vacuo
9. customThe residue was purified by flash chromatography on silica (eluant pet. ether:EtOAc 85:15)
10. customto give a brown oil