反应详情

A solution of 1-[2-(tert-butyldimethylsilanyloxy)ethyl]-5-fluoro-3,4-dihydro-1H-quinoxalin-2-one from Example 21E (110 mg, 0.34 mmol) and diisopropylethylamine (77 μl, 0.44 mmol) in THF (8.0 ml) and a solution of phosgene in toluene (20%, 233 μl, 0.44 mmol) were stirred together for 2 h. A solution of 4-aminomethyl-N-(2-furan-2-ylphenyl)-3,N-dimethylbenzamide from Example 21D (108 mg, 0.34 mmol) and diisopropylethylamine (77 μl, 0.44 mmol) in THF (5.0 ml) was added and the mixture was stirred for 18 h and evaporated in vacuo. The residue was directly in the next step of the synthesis as described in Example 21G.

1. customevaporated in vacuo
2. customThe residue was directly in the next step of the synthesis